A histopathological study on the organs other than lungs of the mice with Chlamydia pneumoniae infection
- VernacularTitle:肺炎衣原体感染小鼠肺外脏器病理改变研究
- Author:
Jie YING
;
Yi SHI
;
Huawen ZHAN
- Publication Type:Journal Article
- Keywords:
Chlamydia pneumoniae;
Animal model;
Histopathology
- From:
Chinese Journal of Respiratory and Critical Care Medicine
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the histopathology of liver,spleen and heart in mice model with Chlamydia pneumoniae ( C pneumoniae ) pneumonia Methods The Icr mice were inoculated with C pneumoniae ,strain CWL 029,by the intranasal or intravenous routes After a single inoculation,mice were killed on the 1st,3rd,7th,14th,21st,28th and 60th day separately Specimens of spleen,liver and heart were obtained from the acute stage of C pneumoniae pneumonitis and stained with hematoxylin eosin Results After inoculation of C pneumoniae ,there were infiltration of neutrophils and macrophages in the spleen and necrosis of hepatocytes The histopathology of iv inoculation group was more serious than that of intranasal inoculation group No pathology changes were observed in heart Conclusions After iv inoculation of C pneumoniae ,the histopathologic changes appeared in the tissue of liver and spleen correspondingly,and the changes were more serious than that of iv inoculation group This study demonstrated that C pneumoniae was mainly limited to lungs and dissemination of C pneumoniae was seldom
