THE EFFECT OF KERATIN 13 GENE ON LARYNGEAL CARCINOGENESIS
- VernacularTitle:Keratin13基因在喉癌发生中的作用
- Author:
Zhenming XU
;
Xinghe SUN
;
Guang HE
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
genes, keratin 13;
gene deletion;
loss of ieterozygosity
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of Keratin 13 gene in laryngeal carcinogenesis. Methods To detect the deletion frequency of keratin 13 sequence indirectly by LOH analysis at DNA level using 5 STR primers within and near keratin 13 gene in 100 cases. Results LOH was found in all of the microsatellite loci, and the LOH frequencies were 30.48%, 26.02%, 21.62%, 37.66% and 21.51% at D17S1964E, D17S2092, D17S791, D17S1665, and D17S808 positions respectively. The frequencies of LOH were not related to the type of laryngeal carcinoma. Conclusion Keratin 13 gene might play an important role in the laryngeal carcinogenesis,and further research is necessary to confirm it.
