EFFECTS OF IL-1 AND IL-4 ON THE EXPRESSION OF p27 AND CDK_2 IN RAT GLOMERULAR MESANGIAL CELLS IN VITRO
- VernacularTitle:IL-1和IL-4对肾小球系膜细胞p27和CDK_2表达的影响
- Author:
Jinghong ZHAO
;
Huibiao YANG
;
Yunjian HUANG
- Publication Type:Journal Article
- Keywords:
interleukin-1;
interleukin-4;
kidney glomerulus;
gene products, rex;
cyclin-dependent kinases
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the effects of interleukin-1 and interleukin-4 on the expression of p27 (one of the negative cell-cycle proteins) and CDK 2 (cell-cycle depending kinase, one of the positive cell-cycle proteins) on renal mesangial cells of rat in vitro, and to analyze their significance. The results showed that the proliferation of mesangial cells was induced markedly by interleukin-1, while the expression of p27 was down-regulated and that of CDK 2 was up-regulated. All of above changes were prevented by interleukin-4. The results suggested that the responses of rat renal mesangial cells to interleukin-1 and interleukin-4 were closely related to the changes in the expression of p27 and CDK 2.
