Application of MRI for assessment of myocardial viability in a pig model
- VernacularTitle:梗死心肌的MRI评价及病理对照实验研究
- Author:
Yanping SUN
;
Xiangke DU
;
Lei CHEN
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Magnetic resonance imaging;
Image enhancement;
Animals, laboratory
- From:
Chinese Journal of Radiology
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relationship between the delayed enhanced area on contrast enhanced MRI to the infarct area on pathologic examination in order to offer the groundwork for clinic in the assessment of myocardial viability by MRI Methods Application of short axial view of delayed contrast enhanced MRI was assessed in a pig model of nonreperfused and reperfused myocardial infarction After excision, the hearts were sectioned into short axial slices, and all slices were stained with TTC The signal intensity on the delayed contrast enhanced MRI of the infarct area was compared with that of the normal area The extent of delayed enhanced area on contrast enhanced MRI was also compared with the extent of the infarct area on TTC stained sections Results On delayed contrast enhanced MRI, the signal intensity of the 7-10 day-old infarct area was much higher than that of normal area In nonreperfusion group, the signal intensity of infarct area(20 81?6 49)was 7 76 times than that of normal area(2 68?1 10)( t =11 68, P 0 05)in nonreperfusion 7-10 day-old myocardial infarction, and the extent of delayed enhanced area (12 52?5 93)% was larger than the extent of infarct area(11 13?5 81)% ( t =-14 48, P
