Advances in anti-tumor therapy targeting the EGFR family of receptor tyrosine kinases
- VernacularTitle:以EGFR家族受体酪氨酸激酶为靶点的抗肿瘤治疗研究进展
- Author:
Weijia KONG
;
Jiandong JIANG
- Publication Type:Journal Article
- Keywords:
EGFR family;
receptor tyrosine kinases;
anti-tumor the rapy;
monoclonal antibodies;
bispecific antibodies;
tyrosine kinase inhibitors;
gene therapy
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases have close connection with the initiation, progression and progn osis of various malignancies. Recently, several approaches such as monoclonal an tibodies, bispecific antibodies, low molecular weight tyrosine kinase inhibitors and gene therapy targeting the EGFR family of receptors for anti-tumor therapy have been developed, some of which are currently undergoing clinical trials. Th ey are generally well tolerated, and have shown encouraging clinical efficacy in a variety of tumor types.
