Regulation of G protein-coupled receptor kinase activity and inflammatory injur y of cell
- VernacularTitle:G蛋白偶联受体激酶活性调控与细胞炎性损伤
- Author:
Yingdeng WANG
;
Gengyun SUN
- Publication Type:Journal Article
- Keywords:
G protein-coupled receptor kinase(GRKs);
G protein-coupled receptor;
inflammatory mediator;
cell injury;
signal transduction
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
G protein-coupleed receptor kinases (GRKs)not only regulates phosphorylation of G protein-coupled receptor which mediates receptor desensitization and initiates profound impairment of receptor signaling,but also regulates G protein and cytoskeleton. Meanwhile GRKs are regulated by protein kinase A, protein kinase C,actin and calcium/calmodulin. Surface of cell has many kinds of G protein-coupled receptor such as PAF receptor, histamine receptor, thrombine receptor which initiates signal effect of cell injury induced by inflammatory mediator. So GRKs have a certain regulatory role in the process of inflammation-induced cell injury through phosphorates G protein-coupled receptor.
