Mitochondria:new intracellular pharmacological target
- VernacularTitle:线粒体:新的细胞内药物作用靶点
- Author:
Jiangang LONG
;
Zhencheng WANG
;
Xuemin WANG
- Publication Type:Journal Article
- Keywords:
pharmacological target;
mitochondria;
reactive oxygen s pecies(ROS);
permeability transition pore (PTP);
mitochondrial ATP-regulated po tassium channel(mitoK ATP )
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria not only acts a key role in en ergy generating process within the cell, but also is intimately associated with some important even ts in cells, such as apoptosis, generation of reactive oxygen species, lipid met abolism etc. For its special structure and function, mitochondria, as the pharma cological target for many agents, interacts with drugs extensively. Learning the interaction between mitochondria and drugs will greatly contribute to the under standing of the mechanism of the drugs, the design of new agents and the avoidan ce of the drug toxicity and side effect. This review is to present the related p roperties of mitochondria and its interactions with classical mitochondrial-tar geted drugs.
