Pirh2 and tumor
10.3760/cma.j.issn.1673-422X.2012.011.008
- VernacularTitle:泛素连接酶Pirh2在肿瘤中的研究进展
- Author:
Xiaorong WU
;
Dongming LIU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Ubiquitin-protein ligases;
Pirh2
- From:
Journal of International Oncology
2012;(11):824-826,880
- CountryChina
- Language:Chinese
-
Abstract:
Pirh2 (p53-induced protein with a Ring-H2 domain),one of the ubiquitin-protein E3 ligases,can promote p53 degradation via ubiquitin-proteasome pathway,and repress the biological functions of p53.Researchers have found that the Pirh2 is overexpressed in many cancers,which suggests Pirh2 is probably correlated with tumorigenesis and cancer development,and it may become a promising cancer therapeutic target.
