Protective effects of doxepin on focal cerebral ischemia-reperfusion injured rats
- VernacularTitle:多塞平对大鼠局灶性脑缺血再灌注损伤的保护作用
- Author:
Biansheng JI
;
He JI
;
Guoqing LIU
- Publication Type:Journal Article
- Keywords:
doxepin;
cerebral ischemia-reperfusion;
NO;
NOS;
[Ca 2+ ] i
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe protective effects of doxepin on focal cerebral ischemia-reperfusion(I-R)injured rats. METHODS 120 rats were randomly divided into ischemia-reperfusion group,doxepin, nimodipine group and sham-operated group respectively, ischemia-reperfusion model was made by using the suture emboli method, the content of NO and MDA, activities of NOS and SOD in the cerebral tissues and the intracellular [Ca 2+ ] i in the cerebral cortex were determined respectively. RESULTS The content of NO, MDA and [Ca 2+ ] i and the activities of NOS decreased and the activities of SOD increased significantly in the doxepin and nimodipine group compared with ischemia-reperfusion group respectively(P
