Effects of chrysophanol on memory impairment mice and its mechan ism analysis
- VernacularTitle:大黄酚对小鼠记忆障碍的作用及其机制分析
- Author:
Lixia SHEN
;
Shujuan LI
;
Danshen ZHANG
;
Xiaohua DONG
;
Haixia WU
;
Wei LI
- Publication Type:Journal Article
- Keywords:
chrysophanol;
AlCl 3;
learning and memory;
GSH-px;
SOD;
oxygen free radicals
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the protective effects and mechanism of chrysophanol on learning and memory impairment of mice with acute senile model induced by AlCl 3. METHODS After sc of AlCl 3 60 mg?kg -1 for 7 d and ip chrysophanol 10,1,0 1 mg?kg -1 for 15 d, using step-through test and step-down test, the effect of chrysophanol on learning and memory was observed and the superoxide dismutase (SOD) activities in cerebrum and glutathione peroxidase (GSH-px)activities in plasma and cerebrum were measured. RESULTS Chrysophanol 10,1,0 1 mg?kg -1 significantly improved me mory impairment induced by AlCl 3 and enhanced the activities of GSH- px and SOD. CONCLUSION Chrysophanol showed protective effect on br ain memory impairment of mice in acute senile model induced by AlCl 3, perhaps the mechanism is involved in enhancing the activities of GSH-px and SOD, cleari ng away the oxygen radicals, protecting the brain neurons from the harm of lipop eroxide.
