The effects of interleukin-6 on the development of autoimmune diabetes in NOD mouse
- VernacularTitle:重组人IL-6对NOD小鼠IDDM发病的影响及机制研究
- Author:
Ming XIANG
;
Nicolett FERDINANDO
- Publication Type:Journal Article
- Keywords:
IDDM;
IL-6;
NOD mice;
cyclophosphamide
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the anti-inflammatory properties of IL-6 on the development of IDDM(insulin dependent diabetes mellitus) in NOD mouse. METHODS IL-6 was administered exogenously in female NOD mice (spontaneous model) and cyclophosphamide-treated NOD mice (accelerated model) respectively. During the study period, the mice were evaluated for development of diabetes once a week. At the end of experiment, 8 euglycosuria mice from each group were sacrificed for histoimmunological analysis, and the production of TNF-? and IFN-? from spleen lymphoid cells were detected. RESULTS The incidence of IDDM in spontaneous model(33%) were significantly reduced after 12 weeks of treatment. TNF-?(P
