Roles of conncctive tissue growth factor in the fibrosis of manchurian dutchmanspipe induced tubulointerstitial nephropathy
- VernacularTitle:结缔组织生长因子在关木通相关肾小管间质肾病肾间质纤维化中的作用
- Author:
Li YANG
;
Xiaomei LI
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Manchurian dutchmanspipe;
Fibrosis;
Connective tissue growth factor;
Transforming growth factor-?1;
Tubulointerstitial nephropathy
- From:
Chinese Journal of Nephrology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe fibrosing-associated indicators in manchurian dutchmanspipe induced tubulo-interstitial nephropathy (GMT-TIN), and try to give a clue to the mechanism of GMT-TIN's unusual fibrosis. Methods Immunohislochemical SP method was applied to detect the expression of CTGF, TGF-?1, ?-SMA, FN and collagen Ⅳ in the renal biopsy specimens of 22 cases of GMT-TIN. Relationships among the above fibrosing-associated indicators and their correlations with the degree of interstitial fibrosis were further analyzed. Results Highly expressed ?-SMA, FN and collagen Ⅳ were detected in the renal interstitium of all the GMT-TIN patients. Expression of the above indicators increased with the aggravating of chronic lesion ( P
