Interference of valsartan on blood pressure and plasma angiotensin Ⅱ,aldosterone in salt sensitive essential hypertensive patients
- VernacularTitle:缬沙坦对盐敏感性高血压患者血压及血管紧张素Ⅱ和醛固酮水平的干预作用
- Author:
Liqun HU
;
Qiyun CAI
;
Weidong WANG
;
Jun LIU
- Publication Type:Journal Article
- Keywords:
pharmacodynamics;
valsartan;
salt sensitive;
hypertensive;
angiotensin Ⅱ;
aldosterone
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the interference of valsartan on blood pressure and plasma angiotensin Ⅱ (ang Ⅱ), aldosterone (ALD) in salt sensitive essential hypertensive patients. METHODS: Eighty-four adult hypertensive patients were enrolled in study, and the salt sensitivity was determined by acute intravenous salt water loading according to Sullvan's criteria. The change of blood pressure and plasma ang Ⅱ, and ALD were compared before and after the treatment. RESULTS: At the end of 2, 4, 6, and 8 weeks, patients with salt sensitive essential hypertensive (group ss) and no salt sensitive essential hypertensive (group nss) were measured. The results showed that sitting systolic blood pressure (SiSBP) was decreased by 17.5 ? 4.3 and 11.0 ? 1.4 mmHg, and sitting diastolis blood pressure (SiDSP) was decreased by 17.0 ? 3.7 and 7.3 ? 1.1 mmHg after the treatment. It was found that patients showed significantly higher plasma ang Ⅱ and lower plasma ALD in group ss and group nss. CONCLUSION: Valsartan can significantly control SiSBP and SiDBP for both groups, interfered plasma angiotensin Ⅱ and I aldosterone, and be more effective for patients with salt sensitive essential hypertensive.
