Anti-inflammatory and antipyretic effects of total alkaloids of Aconitum sungpanense Hand-Mazz
- VernacularTitle:松潘乌头总碱的抗炎解热作用
- Author:
Junying YANG
;
Yuelan DANG
- Publication Type:Journal Article
- Keywords:
pharmacology;
total alkaloids of Aconitum sungpanense Hand-Mazz;
anti-inflammatory;
antipyretic;
indomethacin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the anti-inflammatory and antipyretic effects of total alkaloids of Aconitum sungpanense Hand-Mazz (TAS). METHODS: The inflammatory models were established by injection different inflammatory agents in mice and rats, and the fever model by the intravenous injection of vaccine of typhoid and paratyphoid in rabbits. RESULTS: TAS ( 0.3 - 0.6 mg?kg -1 ,ip) inhibited the edema of hind paw induced by injection of fresh albumen, and formaldehyde in rats, the ear swelling induced by xylene in mice, and the proliferation of granule induced by injection of agar in rats. TAS lowered the temperature of feverish rabbits. CONCLUSION: TAS shows marked anti-inflammatory effect on both acute and chronic inflammation, and antipyretic effect.
