STUDY ON LOW BLOOD PRESSURE RESUSCITATION IN TREATMENT OF UNCONTROLLED TRAUMATIC HYPOVOLEMIC SHOCK IN RATS
- VernacularTitle:低血压复苏治疗出血未控制的创伤失血性休克的实验研究
- Author:
Zonghai HUANG
;
Yinggang SUN
;
Zho LI
- Publication Type:Journal Article
- Keywords:
shock, traumatic;
resuscitation;
hypotension;
rats
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the significance of low blood pressure (permissive hypotension) resuscitation in the treatment of uncontrolled traumatic shock. A traumatic shock animal model was replicated in Sprague Dawlay rats, the animals were randomly devided into non resuscitation group, traditional resuscitation group and low blood pressure resuscitation group. Prothrombin time(PT), activated pactial thromboplastin time(APTT) and oxygen partial pressure in tissues, including skeletal muscles, liver and small intestine, were determined before and after shock. Meanwhile, hemodynamic parameters of the rats and their survival time were monitored and recorded. The data showed that there were statistically significante difference in PT, APTT and amount of blood loss during shock between traditional resuscitation group and the other two groups. Low blood pressure (permissive hypotension) resuscitation could significantly improve oxygen partial pressure in tissues and prolong the mean survival time. The data suggested that low blood pressure resuscitation was a more rational strategy to improve the prognosis in rats with uncontrolled traumatic shock than traditional resuscitation strategy.
