Efficacy of sublingual immunotherapy in children with perennial allergic rhinitis
10.3969/j.issn.1671-8348.2013.30.012
- VernacularTitle:舌下免疫治疗儿童常年性变应性鼻炎疗效观察
- Author:
Lisheng XIE
;
Yinzhu JIANG
;
Qun HUANG
- Publication Type:Journal Article
- Keywords:
dermatophagoides farinae;
rhinitis,allergic,perennial;
child
- From:
Chongqing Medicine
2013;(30):3622-3623,3625
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of the sublingual immunotherapy in children with perennial allergic rhinitis caused by mites .Methods A total of 61 pediatric patients with perennial allergic rhinitis caused by mite in otorhinolaryngology clinic were collected .The children were randomized into two groups :27 cases were divided into sublingual dust mite drops group(group A) , and 34 cases were divided into conventional treatment group (group B) .The symptom scores and sign scores of allergic rhinitis were observed after 6 months ,1 year and 2 years of treatment .Both the efficacy at the end of treatment and the rate of recurrence following 2 years were compared between the two groups .Results After six month of treatment ,the symptom scores in group A was reduced to (3 .70 ± 1 .54)scores ,higher than group B(2 .82 ± 1 .40)scores ,while sign scores in group A was reduced to (1 .19 ± 0 .68)scores ,having no statistically significance compared with group B ,Both symptom scores and sign scores were not changed sig-nificantly after 1 and 2 years of treatment .The efficacy evaluation was 74 .07% in group A ,and 82 .35% in group B .The difference had no statistical difference .The recurrence rate in group A was 29 .63% following 2 years after terminal treatment ,and was superi-or to those in group B (94 .12% ) ,with significant difference(P<0 .01) .Conclusion Dust mite drops sublingual immunotherapy is effective measures for the treatment of children with allergic rhinitis caused by mites .
