GENE EXPRESSION OF p38 MITOGEN-ACTIVATED PROTEIN KINASE AND ITS MAPKKs IN HYPERTROPHIC SCARS
- VernacularTitle:增生性瘢痕内p38丝裂素活化蛋白激酶及其MAPKKs基因的表达
- Author:
Wei CHEN
;
Xiaobing FU
;
Xiaoqing SUN
- Publication Type:Journal Article
- Keywords:
p38 MAP kinase;
mkk3 gene;
mkk6 gene;
scar
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the change in gene expressions of p38 mitogen-activated protein kinase (p38MAPK) and its upstream signal-regulated molecule (mkk3 and mkk6) in normal skin versus hypertrophic scars underlying its potentially biological significance. Total RNAs were isolated from 8 specimens of hypertrophic scars and 8 specimens of normal skin, then they were purified to mRNAs, and the gene expression of mkk3, mkk6 and p38MAPK was examined with reverse transcription-polymerase chain reaction (RT-PCR). The results showed that the intensities of gene expression of mkk6 and p38MAPK were weak in normal skins, while the expression of these 2 genes was significantly elevated in hypertrophic scars compared with normal skins (P0.05). In hypertrophic scar, the elevation of mkk6 and p38MAPK gene expression, which plays pilot roles in cell proliferation, may be one of the mechanisms controlling the formation of hypertrophic scars.
