INFLUENCE OF FRACTIONED RADIATION ON THE SENSITIVITY OF NCI-H446 CELL LINE TO CHEMOTHERAPEUTIC DRUG
- VernacularTitle:外照射对体外培养的小细胞肺癌细胞系药物敏感性的影响
- Author:
Yunyou DUAN
;
Peng SONG
;
Qing NIE
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
radiotherapy;
RNA;
chemosensitivity;
mitomycin
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the effect of fractioned radiation on the sensitivity of NCI-H446 small cell lung cancer cell line to chemotherapeutic drug and its mechanism. Exponentially growing NCI-H446 cells were exposed to 50 Gy radiation which was administered in 25 fractions with 2 Gy per fraction. The survival rate of NCI-H446 cell line was observed after the interference of different concentration of Mitomycin C given before and after fractioned radiation treatment. The survival rate of the radiated cells was higher than that of the unradiated cells with the same concentration of Mitomycin C(P
