A STUDY ON RELATIONSHIP BETWEEN HEPATOCYTE GROWTH FACTOR AND EXPRESSION OF ITS C-MET RECEPTOR AND POSTOPERATIVE RECURRENCE OF SMALL HEPATOCELLULAR CARCINOMA
- VernacularTitle:肝细胞生长因子及其c-Met受体表达与原发性小肝癌术后复发关系的初步研究
- Author:
Kai JIANG
;
Zhiqiang HUANG
;
Ningxin ZHOU
- Publication Type:Journal Article
- Keywords:
hepatocyte growth factor;
c-Met receptor;
hepatocellular carcinoma
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible relationship between the changes in the serum level of hepatocyte growth factor (HGF) and the tumor c-Met expression in postoperative patients with small primary hepatocellular carcinoma (SHCC) and the recurrence of the cancer. Methods We examinated the HGF concentration in serum by ELISA within 1 day before and 3 days after operative removal of the tumor, and also determined the expression of c-Met protein in the tumor and non-tumor tissue by Western and Northern blotting in situ. Results The serum HGF concentration 1-day before or 3-days after operation was 0.64?0.15ng/ml and 1.41?0.28ng/ml, respectively. There was statistically significant difference between them (P
