EXPRESSION CHANGES IN CELLULAR PROLIFERATIVE NUCLEAR ANTIGEN IN SPINAL CORD AFTER HYPERBARIC OXYGEN TREATMENT FOR ITS INJURY IN RAT
- VernacularTitle:高压氧治疗脊髓损伤后脊髓组织中增殖细胞核抗原的表达变化
- Author:
Jian FANG
;
Yiqun FANG
;
Jingchang LIU
- Publication Type:Journal Article
- Keywords:
hyperbaric oxygenation;
spinal cord injuries;
proliferating cell nuclear antigen
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of hyperbaric oxygen (HBO) on cellular proliferative nuclear antigen (PCNA) in spinal cord after its injury (SCI), we observed the pathological changes and the expression change in PCNA in spinal cord after the injured rats were treated with HBO. The results showed that there were hemorrhage, edema, vacuolation of nerve cells in spinal cord, disorder and fragmentation in nerve fibers after injury. PCNA was strongly positively expressed in neurons. The results in 0.1MPa HBO group were similar to that of non-treatment group, while in 0.25MPa HBO group, edema was abolished, the cellular vacuolation was lessened, the morphology of nerve cells recovered, the structural configuration appeared normal, and the degree of PCNA expression was decreased compared with the injury group. These results suggested that PCNA could serve as a cellular proliferative index; HBO could prevent or alleviate the pathological changes of SCI, and could effectively promote the repair of the injury of the spinal cord.
