Biocompatibility study of acellular bladder matrix patch
10.3969/j.issn.1671-8348.2014.03.016
- VernacularTitle:脱细胞膀胱基质补片的生物相容性研究
- Author:
Xuemei FAN
;
Huicheng XU
;
Zhaoli WANG
- Publication Type:Journal Article
- Keywords:
acellular bladder matrix;
biocompatibility;
cytotoxicity test;
hemolysis test;
vaginal implant test
- From:
Chongqing Medicine
2014;(3):298-300,303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the biocompatibility of acellular bladder matrix patch as the pelvic floor repair alternative ma-terial .Methods The combination of in vivo and in vitro biological experiments including cytotoxicity ,haemolysis and vaginal im-plant tests were employed to evaluate the biocompatibility of this material .Results In the cytotoxicity test ,the material toxicity was the grade 0-1 .The hemolysis rate of the material extract liquid was 1 .5% .The general and histological observation showed that the material did not cause the host immunologic rejection and led to slight foreign body reaction after implanting ,which was ba-sically degraded in 12 weeks after transplantation .Conclusion Acellular bladder matrix exhibits better biocompatibility ,but needs to adjust its degradation rate in order to adapt to the requirements of pelvic floor repair operation .
