The pathogenic mechanism and therapeutic existing state of diabetic nephropathy
- VernacularTitle:糖尿病肾病的发病机制与治疗现状
- Author:
Xinming LIU
;
Xiaocheng LIU
- Publication Type:Journal Article
- Keywords:
Hyperprotein chow;
Diabetic nephropathy;
Glomerular filtration rate;
Intercellular adhension molecule-1
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Hyperprotein chow can increase perfusion and filtration of glomerulus,and so result in kidney hypertrophy and damage.Monocytes and macrophages are considered to be a characteristic of diabetic nephropathy(DN),and play a key role in the glomerular sclerotic lesions.At present,hyperprotein chow,infiltration of monocytes and macrophages and overproduction of intercellular adhension molecule-1(ICAM-1) are thought to be involved in the progression of DN.Hyperprotein chow resulting in hyperfiltration may be one of potential mechanisms of ICAM-1 upregulation.