Orphan G protein-coupled receptors and their significance as novel drug targets
- VernacularTitle:孤儿G蛋白偶联受体及其作为新药靶点的重要意义
- Author:
Yongxue LIU
;
Shaoping YU
- Publication Type:Journal Article
- Keywords:
orphan GPCRs;
ligand;
drug tar-get;
reverse pharmacology
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
G protein-coupled receptors(GPCRs) are the largest and most diverse group of trans-membrane proteins involved in signal transduction. They have been playing key roles in drug discover-y. Increasing orphan GPCRs (oGPCRs) whose endogenous ligands and functions are still to be identified have been discovered in recent years. It is obvious that oGPCRs might be the most important targets for innovating drugs.
