A drug target for Alzheimers disease: ?-secretase
- VernacularTitle:治疗阿尔采末病的药物靶点:?-分泌酶
- Author:
Yuehua WANG
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
?-secretase;
Alzheimers disease;
?-amyloid peptide
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT Recent research suggests that the ?-amyloid peptide (A?) is central to the pathophysi-ology of Alzheimers disease (AD). Amyloid plaques, primarily composed of A?, have significant neurotoxic effects. So it is therapeutic strategies for AD to lower the production of A? in the brain. A? is a product of catabolism of amyloid precursor protein ( APP) by ?-secretase and y- secretase. BACE ( ?-secretase) exhibits all the properties of the ?-secretase, and as the key rate-limiting enzyme that initiates the formation of A?, BACE is an attractive drug target for AD. The recent research of ?-secretase is reviewed in this paper.
