Effects of iptaklim hydrochloride on glutamate induced cytotoxicity in cultured pheochromocytoma (PC12) cells
- VernacularTitle:盐酸埃他卡林对谷氨酸所致PC12细胞损伤的保护作用
- Author:
Yingli ZHANG
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
iptakalim hydrochloride;
PC12 cell;
glutamate
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the protective effects of iptakalim hydrochloride (Ipt) against glutamate induced neurotoxity. METHODS Neurotoxity injury was induced by with glutamic acid in PC12 cells. The cell viability was measured by MTT assay. RESULTS Ipt at the concentrations of 1 ? 1(T-10 - 1 ? 1(T4 mol ? L-1 markedly mitigated glutamate-induced neurotoxicity. The protec- live effect was nullified by glibenclamide, an ATP-sensitive potassium channel antagnist. CONCLUSION Ipt provides neuroprotection on glutamate-induced cytotoxixity in cultured PC12 cells and this effect may be related with ATP-sensitive potassium channels.
