The effects of scoparone on the content of IL-4 and IFN-r in asthmatic guinea pigs
- VernacularTitle:滨蒿内酯对哮喘豚鼠IL-4和IFN-?含量的影响
- Author:
Chun LIU
;
Zhi LI
;
Guojun LU
;
Zan TENG
;
Peng YU
- Publication Type:Journal Article
- Keywords:
scoparone;
asthma;
animal model;
IgE;
IL-4;
IFN-r
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the changes of IgE, IL-4 and IFN-y in serum and pulmonary tissue homogenate of asthmatic guinea pigs and the effects of scoparone on them. METHODS To divide animals into three groups: control, asthma and scoparone treatment groups. Choose the model guinea pigs of asthma sensitized with OA, and observe the changes of IgE, IL-4 and IFN-r in serum and pulmonary tissue homogenate of asthmatic guinea pigs and the effects of scoparone on them by means of chemolumi nescence, radio immunoassay, enzyme-linked immunoabsordent assay. RESULTS IgE and IL-4 in serum and pulmonary tissue homoge-nate of asthmatic guinea pigs obviously increase (P
