Effects of cistanche desertica polysacchrides on the nitric oxids and apoptosis of lung in aging mice
- VernacularTitle:肉苁蓉多糖对衰老小鼠肺一氧化氮及细胞凋亡的影响
- Author:
Yun SUN
;
Feng XU
;
Xuanxuan YANG
;
Dejun WANG
;
Hongquan ZHANG
- Publication Type:Journal Article
- Keywords:
lung;
aging;
NO;
SOD;
apoptosis
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To evaluate the effect of METHODS 2 month-old mice were fed routinelycistanche desertica polysacchrides(CDP) on the ni- for 11 mounths to establish the model of naturallytric oxids(NO) ,superoxide dismutase(SOD) in se- aging mice. The cistanche desertica polysacchridesrum and apoptosis of lung cell in aging mice. 25, 50, 100 mg ?kg~' were administrated respec- lively to the mice po. then investigated the concentration of NO, SOD and the morphological changes of apoptosis by fluoromicroscope. RESULTS Aging could induce the lung cell apoptosis, decrease the level of SOD, and increase the level of NO as well. The cistanche desertica polysacchrides signif- icantly ameliorated the lung cell apoptosis; decreased the level of NO, improved the activity of SOD. CONCLUSION Cistanche desertica polysac-chrides have ameliorating and postponing effects on the regressive changes in the lung of aging mice.
