Progress of cyclooxygense-2 inhibitors in treatment of Alzheimer's disease
- VernacularTitle:环氧合酶-2抑制剂防治阿尔茨海默氏病的进展
- Author:
Yuanqi SU
;
Zhi DONG
- Publication Type:Journal Article
- Keywords:
pharmacology;
review;
cyclooxygense-2 inhibitors;
nonsteroidal anti-inflammatory drugs;
Alzheimer's disease
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is the most common cause of dementia in the elderly population. The occurrence of dementia correlates with inflammation. Inflammation processes may play a critical role in the pathogenesi s of the degenerative changes and cognitive impairments associated with Alzheime r's disease. Cyclooxygense-2 (COX-2) inhibitors are reported to be e ffective in reducing the risk of developing AD or cognitive impairments. Studies on this field are of important significance in the understanding the pathogenes is and therapeutic measures for AD. This review will discuss the progress in the treatment of Alzheimer's disease by COX-2 inhibitors.
