Transport mechanism of ?-lactam antibiotics in intestine and kidney
- VernacularTitle:?-内酰胺抗生素的肠道及肾脏转运机制
- Author:
Xiuhong ZHANG
;
Jianguo SONG
- Publication Type:Journal Article
- Keywords:
pharmacology;
review;
?-lactam antibiotics;
PEPT;
O ATs;
OCTs;
P-gP
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Some transport systems are foun d both in intestine and kidney with functional and morphological similarities, suc h as peptide transport system, organic anion transport system, organic cation tr ansport system, and P-glycoprotein-mediated transport system. All these transp ort systems participate in the transporting process of ?-lactam antibiotics in different extent. It suggests that inhibitors of renal transport may also affec t the drug absorption of the intestine.
