Antitumor effects of losartan in EAC mice
- VernacularTitle:洛沙坦抗小鼠艾氏腹水癌的作用
- Author:
Fang CHEN
;
Tie WU
- Publication Type:Journal Article
- Keywords:
pharmacology;
losartan;
5-FU;
EAC;
antitumor effec t
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the antitumor e ff ects of losartan in EAC mice. METHODS: The inhibitory rates of t umor growth and the ratio of extending viability were observed in EAC mice in th ree groups given losartan, 5-FU and NS, respectively. RESULTS: Comparing with the control groups, the inhibition to tumor growth was 46.3 % in losartan ( 12.5 mg?kg -1 ) group. But losartan did not lengthen life time in EAC mice. The inhibition to tumor growth was was 31.5 % in 5-F U (5 mg?kg -1 ) group. CONCLUSION: Losartan can inhibit the tumor growth of EAC, but not lengthen life time of the animals.
