Influence of tripterygium wilfordii on the children wit h nephrotic proteinuria
- VernacularTitle:雷公藤多苷片对小儿肾性蛋白尿的影响
- Author:
Guohua HU
- Publication Type:Journal Article
- Keywords:
pharmacodynamics;
tripterygium wilfordii;
nephritic proteinuria;
children
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the value and the effect of tripterygium wilfordii on decreasing proteinuria in the primary and secondary nephropathy synd rome in children. METHODS: 30 patients were confirmed the pathol ogy classification, and given tablets of tripterygium wilfordii by 1.5 kg?d -1 for 4 weeks. 24-hour urine volume and gastrointestinal reaction were obser ved, and regularly the 24-hour proteinuria quantity, hepatic and renal function , peripheral blood, and serum albumin were examined. RESULTS: 14 of 30 patients were effective after the treatment, 12 patients were improved, 7 patients were effective after 1-week treatment, and 9 patients were effective after 2 weeks. Individual patients had moderate gastrointestinal disorder; a few patients had modest ALT increase in early therapy; and all recovered after cont inuous treatment. The value of WBC in 3 patients decreased to 3.5 ?10 9 L -1 in the whole course, but, it did not affected the administration. A ll patients had normal renal function. CONCLUSIONS: Tripterygi um wuilfordii can effectively decrease proteinuria, and improve the symptom of primary and secondary nephropathy syndrome in children.
