Relations between Breast Cancer Treatment Strategy and HER-2 Overexpression

VernacularTitle:乳腺癌与HER-2过表达的关系及治疗策略
Author: Kun TANG
Publication Type:Journal Article
Keywords: breast neoplasms; epidermal growth factor receptor-2; drug therapy
From: Chongqing Medicine 2013;(29):3498-3499,3502
CountryChina
Language:Chinese
Abstract: Objective To study the expression of HER-2 expression in breast cancer and the significance ,and to look into rela-tions between axillary lymph node metastasis in patients ,TNM ,T staging ,histological type ,PR and ER as well as drug treatment strategy of HER-2 over expression .Methods Eighty-four cases of patients admitted by this hospital from May 2008 to May 2012 diagnosed with breast cancers were selected ,84 patients were examined in this hospital ,and conditions of patients were classified , they were tested by use of Streptavidin-Peroxidase (SP method) ,test results and samples of normal breast tissues were compared . Results The level of HER-2 factor receptor in mammary gland tissues of patients with breast cancer was higher than that within normal breast tissue ,the difference was statistically significant (P< 0 .05) ,the expression of HER-2 receptor in patients with breast cancer tissue was unrelated to TNM staging ,histological type (P values were 0 .256 and 0 .157 respectively) .Conclusion HER-2 plays a key role in the identifying the generation and development of the breast cancer ,and it can provide the basis for the diagnosis ,multi-targeted therapy of patients with breast cancers .