EXPERIMENTAL STUDY ON ELECTROPORATION ENHANCING IMMUNOLOGICAL EFFECT OF HBV DNA VACCINE
- VernacularTitle:电脉冲肌注法增强治疗型HBV DNA疫苗免疫效果的实验研究
- Author:
Fuqiang YANG
;
Yonggang ZHAO
;
Guangmin CHEN
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
vaccines, DNA;
vaccination;
in vivo electroporation(EP)
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we applied in vivo electroporation(EP) for HBV DNA vaccine administration to improve the cell transfection rate of plasmid DNA and to enhance the immune response. In BALB/c mice (8 mice in each group), the luciferase activity (16170?12533RLU) was 4 digits higher than that of the non EP control (8 02?8 00RLU), the difference between them was very significant ( P
