Research advances in the impact of calpain-10 gene on type 2 diabetes
- VernacularTitle:CALPAIN-10基因与糖尿病相关性研究进展
- Author:
Linlin LI
;
Yueming ZHANG
- Publication Type:Journal Article
- Keywords:
CAPN-10, SNPs, T2DM
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The CAPN10 gene, which encodes calpain-10 ( CAPN10 ), a nonlysosomal cysteine protease expressed in many tissues, including skeletal muscle, liver, and pancreas, was positionally cloned within the NIDDM1 region. This putative diabetes susceptibility gene encodes a 672 amino-acid protein. Horikawa et al, determined that the CAPN10 gene consists of 15 exons and spans 31 kb. Recently, researchers in many countries have examined the impact of CAPN-10 gene on T2DM. The three SNPs existence simultaneously can increase threefold risk of T2DM. The correlation between them with racial diversity is also reviewed.
