INDUCTION OF APOPTOSIS BY COMPOUND "HUANG DAI" TABLET IN ACUTE PROMYELOCYTIC LEUKEMIA
- VernacularTitle:复方黄黛片诱导急性早幼粒细胞白血病细胞凋亡的研究
- Author:
Chen ZHANG
;
Shilin HUANG
;
Yan XIANG
- Publication Type:Journal Article
- Keywords:
arsenicals;
leukemia, myelocytic, acute;
apoptosis;
antigens, CD
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the mechanism of therapeutie effect of compound "Huang Dai" tablet in acute promyelocytic leukemia, twenty one patients with acute promyelocytic leukemia were treated with compound "Huang Dai" tablet. Bone marrow cells of the patients were collected before treatment and after treatment, and membrane differentiating antigen (CD33 and CD11b), cell cycle and the apoptosis correlative protein(Fas and Apo 2.7 )were detected with flow cytometry. Results showed that the expression of CD33 was decreased and that of CD11b increased, G 2 /M phase of cell cycle was blocked, and the expressions of Fas and Apo 2.7 protein were increased significantly in all patents after treatment with compound "Huang Dai" tablet. These results suggested that the mechanism of therapeutic effect of compound "Huang Dai" tablet in acute promyelocytic leukemia was induction of both differentiation and apoptosis of leukemic cells, and cell apoptosis might be related to Fas and Apo2.7 protein.
