Relationship of the phosphodiesterase 4D gene rs153031 polymorphism and the susceptibility of unstable angina pectoris
10.3969/j.issn.1671-8348.2014.05.015
- VernacularTitle:磷酸二酯酶4D基因rs153031多态性与不稳定型心绞痛易感性的研究
- Author:
Hao XU
;
Guoping HE
;
Chuanping QI
;
Lianhong XU
;
Haitao YANG
;
Yichao QIAN
- Publication Type:Journal Article
- Keywords:
angina,unstable;
cyclic nucleotide phosphodiesterases,type4;
gene polymorphism
- From:
Chongqing Medicine
2014;(5):551-552,555
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the phosphodiesterase 4D(PDE4D) gene rs153031 polymorphism and the susceptibility of unstable angina pectoris(UAP) in Chinese Han population of Changwu region .Methods The PDE4D gene rs153031 polymorphism was genotyped by Taqman probe in 172 UAP patients(UAP group) ,as well as in gender-and-age-matched 220 subjects without coronary heart disease(CHD)(control group) .Results In this crowd ,there was PDE4D gene rs153031 poly-morphism in patients with UAP and in subjects without CHD .Compared with control group ,frequencies of GG ,GA ,AA genotypes and G allele of rs153031 in UAP group showed no statistical differences (P> 0 .05) .Conclusion In Chinese Han population of Changwu region ,PDE4D gene rs153031 polymorphism shows no association with the susceptibility of UAP .
