Research progress of signal transduction mechanism of synoviocytes with rheumatoid arhritis
- VernacularTitle:类风湿关节炎滑膜细胞信号转导机制研究进展
- Author:
Min DAI
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
synoviocyte;
cytokine;
signal transduction
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
It has been shown that two pathways of signal transduction are activated under the stimulation of cytokines , such as IL-1?TNF-? ?EGF?TGF-? ?PDGF?IGF-1, secreted by fibroblast-like synoviocytes with rheumatoid arthritis. They are receptor tyrosine kinases-Ras-MAPK pathway and non- receptor tyrosine kinases-JAK-STAT pathway. The former activation plays an important role in chronic synovitis of rheumatoid arthritis. More researches are expected to focus on G-protein-AC-cAMP signal transduction pathway and the internal relations of all kinds of pathways.
