The progress in the mechanisms of methamphetamine neurotoxicity
- VernacularTitle:甲基苯丙胺神经毒性机制的研究进展
- Author:
Junlan ZHOU
;
Jianhui LIANG
- Publication Type:Journal Article
- Keywords:
methamphetamine;
neurotoxicity;
reactive species;
cell apoptosis
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Research into methamphetamine-induced neurotoxicity has experienced a resurgence in recent years. This is due to an increased abuse of the substance internationally. The long-term abuse of methamphetamine will result in neurochemical, neuropathological and behavioral changes. Recent data implicate that dopamine oxidation, glutamate-induced excitotoxicity, disruption of mitochondria, and apoptosis are involved in the injury of methamphetamine to central nervous system. Further, Involvement of cell death-related genes in the neurotoxic effects of methamphetamine is also discussed.
