A new target for antihepatofibrosis:Na~+/H~+ exchangers
- VernacularTitle:抗肝纤维化的新靶点:Na~+/H~+交换泵
- Author:
Houchang CHEN
;
Yonggang LIU
- Publication Type:Journal Article
- Keywords:
Na +/H + exchanger;
liver fibrosis
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Na +/H + exchangers(NHE) are vital transmembrane proteins involved in multiple cellular functions including the regulation of intracellular pH, the control of cell volume and the onset of proliferation, differentiation and apoptosis of cells, hence associated with liver fibrosis due to mediating hepatic stellate cell(HSC) activation and collagen synthesis effects induced by cytokines and oxidative stress. NHE is expected to be a new important target for antihepatofibrosis.
