The experiment study of injectio tanshin on the antiperoxide damage during dissolving thrombus to cure the acute myocardial infarction
- VernacularTitle:丹参注射液在急性心肌梗死溶栓治疗中抗过氧化损伤的实验研究
- Author:
Yi LIU
;
Zhijie XIAO
;
Zhimin QI
- Publication Type:Journal Article
- Keywords:
injectio tanshin;
acute myocardial infarction;
dissolve thrombus;
lipid peroxidation
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the antiperoxide damage of injectio tanshin during dissolving thrombus to cure the acute myocardial infarction(AMI). METHODS AMI model formatted by electricity to irritate the left ventricular branch of coronary artery of open-chest rabbit,and observation aspects including electrocardiogram(ECG),cardiac output and contractility,serumal enzymatic activities and biochemistry and pathology of lipid peroxide extent of myocardial infarction zone. RESULTS By urinate kinase(UK) combining with injection tanshin,abnormal changes of ECG, descending of cardiac contractiles and cardiac output,going up of serum cardiac damage enzyme(CPK-MB and LDH),and the malondialdehyde(MDA)of serum and myocardial infarction zone could be remarkably reduced or avoided during UK dissolving the thrombus to cure AMI rabbits. CONCLUSION Injection tanshin can clearly reduce or avoid lipid peroxidation damage during UK dissolving the thrombus to cure the acute myocardial infarction.
