Effects of taurine on left ventricular hypertrophy in renovascular hypertensive rats
- VernacularTitle:牛磺酸对肾血管性高血压大鼠左室肥厚的保护作用
- Author:
Min ZHENG
;
Jiliang WU
;
Lizhong LI
;
Shihua YIN
;
Cuiyu BAO
- Publication Type:Journal Article
- Keywords:
taurine;
left ventricle hypertrophy;
angiotensin-Ⅱ(AngⅡ);
aldosterone(Ald);
proto-oncogene c-fos;
myocardial collagen
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the preventive effects of taurine on the left ventricle hypertrophy in renovascular hypertensive rats. METHODS Two-kidney 1-clip (2K1C) rats were used to establish the model of renovascular hypertension. The myocardial local aldosterone(Ald) and AngⅡconcentration (MDC,MAC) were measured by radioimmunoassay. Expression of oncogene c-fos mRNA was analyzed by means of in situ hybridization. The myocardial collagen concentration (MCC) was measured by biochemical method. The myocardial tissue structure was observed under the microscope ,and the myocardial fiber diamension (MFD) was measured with micrometer. The linear correlation between MCC, MFD and MAC or MDC was analysed respectively. RESULTS Compared with sham operated rats ,the MCC, MAC, MDC and MFD were significantly increased in 2K1C rats ( P
