Effects of iptakalim hydrochloride on potassium currents in artery smooth muscles
- VernacularTitle:盐酸埃他卡林对动脉平滑肌钾电流的影响
- Author:
Yuge JIANG
;
Xiaofeng YIN
;
Wenyu CUI
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
iptakalim hydrochloride;
patch clamp technique;
smooth muscle cell;
ATP sensitive potassium channel
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of the novel antihypertensive drug iptakalim hydrochloride on potassium currents in artery smooth muscle cells. METHODS The effects of iptakalim hydrochloride on potassium currents in smooth muscle cells derived from rat pulmonary arteries were observed by using patch clamp technique(whole cell recording) after application of the drug in the bath. RESULTS The potassium current-voltage curves ( I-U curves) of smooth muscle cells derived from normotensive rat pulmonary arteries were up-ward shifted by iptakalim hydrochloride(0.1,1,10 and 100 ?mol?L -1 ). Within 5 minutes after application of the drug, the current amplitude could increase to[(118.6?15.9)%, P
