Previous treatment with dopamin to ischemia-reperfusion injury in rats
- VernacularTitle:多巴胺对大鼠移植肾热缺血再灌注损伤的预处理
- Author:
Fang LIU
- Publication Type:Journal Article
- Keywords:
ischemie-reperfusion injury;
renal immunocompetence;
dopmin
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To determine whether the previous treatment with dopamin can reduce renal immunocompetence in rats hot ischemie-reperfusion injury animal model. METHODS The Lewis rats were filled continuously for 48 h with a range density dopamin (2,5,10 ?g?kg -1 ?min -1 ) before hot ischemia. Served as contrast, the male Lewis rats were filled with NaCl. After pressing the left renal artery for 1 hour, we analysed the right renal HO-1 amount, and after 5 d, the left renal was taken for immunohistochemical studies. RESULTS The previous treatment with dopamin can reduce renal monocyte infiltration and expression of MHC-Ⅱ as well as raise renal HO-1 amount. CONCLUSION The previous treatment with dopamin can reduce ischemie-reperfusion injury renal immunocompetence.
