Effects of combined use of heparinoid,aspirin,and losartan on the experimental vascular intima hyperplasia in rats
- VernacularTitle:类肝素、阿司匹林、氯沙坦联合应用抗实验性血管内膜增生的研究
- Author:
Liyan PANG
;
Xubin ZHOU
;
Lixiang WANG
;
Qingfen ZHU
;
Hongyan XU
- Publication Type:Journal Article
- Keywords:
heparinoid(Hep);
aspirin(Asp);
losartan(Los);
TXB_2;
platelet-derived growth factor (PDGF);
proliferating cell nuclear antigen (PCNA)
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the effects of the combination of heparinoid, aspirin and losartan on the experimental vascular intima hyperplasia induced by squeezing carotid artery in rats. METHODS Rats except the normal control group were under operation after two days oral administration once a day. At the second hour after injury, blood coagulation time(CT), time of arterial thrombus formation by electrical stimulus(ATFTES) and the level of TXB_2 in plasma were measured. At the fourteenth day after the surgery, the following indexes were examined: intima/media ratio, intima area ratio, PDGF-B and PCNA immunohistochemistry in carotid artery. RESULTS CT, TATFES increased and the level of TXB_2 decreased in the groups of Hep, Asp and Hep+Asp. The PDGF-B content, the positive ratio of PCNA and the inti- ma/media ratio also decreased in the groups of Hep, Asp, Los, Hep+Asp, Hep+Los and Asp+Los. Compared with single drug or two drugs combination, PDGF-B, positive ratio of PCNA, intima/media ratio and intima area ratio decreased significantly in the group of three drugs combination( P
