Effects of sodium ferulate on nitric oxide synthase and cyclooxygenase in colon of colitis rats
- VernacularTitle:阿魏酸钠对结肠炎大鼠结肠组织一氧化氮合酶和环氧合酶的影响
- Author:
Shaoping LIU
;
Weiguo DONG
;
Dongfang WU
;
Hesheng LUO
;
Jieping YU
;
Qiao MEI
- Publication Type:Journal Article
- Keywords:
sodium ferulate;
colitis;
nitric oxide synthase;
cyclooxygenase
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the anti-inflammation protective effects of sodium ferulate (SF) on colitis rats and its mechanism. METHODS The colitis model of rats was produced by intracolon enema with acetic acid. SF and 5-ASA were used intracolonically for a week. The colon mucosadamage index (CMDI) was evaluated. Nitric oxide (NO), myelopexoxidase (MPO), prostaglandin (PGE_2), and the levels of expression of constitutive nitric oxide synthase(cNOS), induce nitric oxide synthase (iNOS), cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and nuclear factor-kappaBp65(NF-?Bp65) in the rats colon were detected by corresponding kits and immunohistochemical technology. RESULTS SF (200,400,800 mg?kg -1 ) can decrease the extents of CMDI and the levels of NO, MPO, PGE_2, the expression of cNOS, iNOS, COX-2, and NF-?Bp65 in model group in a dose-dependent manner while the expression of COX-1 changes littlely. CONCLUSION SF is a NOS and partial selective COX-2 inhibitor and show therapeutic effect on colitis in rats.
