Anti-exprimental atherosclerosis effects of improved prescription of didang-tang (IPDT) in rabbits and its mechanism
- VernacularTitle:抵当汤改良方抗家兔实验性动脉粥样硬化效应及机制初探
- Author:
Heqing HUANG
;
Peiqing LIU
;
Min HUANG
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
lipid/metabolism;
oxidation;
ceramide;
cell apoptosis;
Chinese herbal medicine
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the effects of improved prescription of Didang-tang (IPDT) on exprimental atherosclerosis(AS) in rabbits and study the possible mechanism. METHODS Lipid plaque area of aortic endothelium was measured by image analysis method. lipid metabolism was measured by enzyme dynamics method, one-step method and immunization photoextinction. Plasma SOD and MDA was measured by microcontent fast detecting method and modified Ba MuGuoFu method. Ceramide was measured by thinlayer scannig; apoptosis of foam cell of aorta lipid plaque was measured by TUNEL method.RESULTS IPDT reduced lipid plaque area of aortic endothelium,regulated lipid metabolism, improved antioxidation of organism, ced ceramide content of aorta lipid plaque and apoptosis of foam cell.CONCLUSION IPDT has good effects of anti-exprimental AS,the possible mechanism maybe related to regulation of lipid metabolism and antioxidation and depression of apoptosis of foam cell.
