The results analysis of the rapid detection of HPV genetype in 282 cervical cancer precursor cases
10.3969/j.issn.1673-4130.2014.11.021
- VernacularTitle:282例宫颈癌前病变快速 HPV 基因检查的结果分析
- Author:
Weihong CHEN
;
Jie LAN
- Publication Type:Journal Article
- Keywords:
human papilloma virus;
thinprep cell test;
genotype;
cervical cancer precursor
- From:
International Journal of Laboratory Medicine
2014;(11):1426-1427,1430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical values of human papilloma virus(HPV)testing in screening for women of early cervical cancer lesion.Methods 282 cases of cervical screening of patients had received cervical exfoliated cells collection,at the same time for a liquid thin-layer cytology test(TCT)and HPV genotyping detection.Abnormal results received histologic examina-tion,the results regarded as the diagnostic gold standard by pathological examination.Results In HPV DNA positive group(126 cases),by liquid based cytology,NILM,ASCUS,LSIL,HSIL and SCC were found in 53,22,32,18,1 cases,respectively.His-topathologic examination positive rate was 42.86%.In HPV DNA negative group(156 cases),there were 133 cases with NILM,16 cases with ASCUS,and 7 cases with LSIL.Histopathologic examination positive rate was 11.54%.Two groups of patients with pathologic positive rate compared,the difference was statistically significant(P <0.01 ).High risk type HPV detection rate in-creased with the increased degree of cervical lesions.Conclusion Women of early cervical cancer and precancerous lesions in the screening line HPV detection has important significance.
