THE EFFECT OF HEPATOCYTE GROWTH FACTOR ON SECRETION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN VASCULAR SMOOTH MUSCLE CELLS AND CARDIOMYOCYTES
- VernacularTitle:肝细胞生长因子对心肌细胞及血管平滑肌细胞、血管内皮细胞生长因子分泌的作用
- Author:
Yifeng JIANG
;
Xiaoyun LIN
;
Shuanghon CHEN
- Publication Type:Journal Article
- Keywords:
endothelial growth factors;
muscle, smooth, vascular;
cardio myocyte
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of hepatocyte growth factor(HGF) on the secretion of vascular endothelial growth factor(VEGF) in cultured bovine coronary artery endothelial cells(BCAEC), bovine coronary artery smooth muscle cells(BCASMC) and mouse cardiomyocytes were observed in vitro . The concentrations of VEGF in BCAEC control and HGF group at 12h were 10.51?2.90pg/ml and 9.31?2.78pg/ml, respectively. The concentrations of VEGF at 12h in BCASMC control and HGF group were 3.35 and 3.93 times of that at 3h respectively, the concentration of VEGF at 3h and 12h in BCASMC HGF group was 2.06 and 2.42 times respectively, of that in control group. The concentrations of VEGF at 12h in cardiomyocyte control and HGF group were 5.43 and 4.09 times, respectively, of that at 3h, and the concentrations of VEGF at 3h and 12h in cardiomyocyte HGF group was 2.74 and 2.06 times, respectively, of that in control group. These results indicated that BCAEC, BCASMC and mouse cardiomyocytes could secrete VEGF, and HGF could promote VEGF secretion in BCASMC and cardiomyocytes, but not in BCAEC.
