PROTECTIVE EFFECT OF YIXINTANG ON ISCHEMIA-REPERFUSION INJURY OF MYOCARDIUM
- VernacularTitle:益心汤对心肌缺血再灌注损伤保护作用的研究
- Author:
Liping CHEN
;
Jun YI
- Publication Type:Journal Article
- Keywords:
Yixintang;
myocardial ischemia;
reperfusion injury;
protection
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effect of "Yixintang" on the protection of the myocardium against ischemia reperfusion injury. Thirty Wistar rats, with their hearts isolated, were randomly divided into three groups: Yixintang group 1 (YXT1, with 0 01g "Yixintang" in each ml K H fluid), Yixintang group 2 (YXT2, with 0 1g "Yixintang" in each ml K H fluid) and control group. Left ventricular systolic output pressure (LVSP), rate of rise of left ventricular pressure (?dp/dt max ), left ventricular end diastolic pressure (LVEDP), heart rate, the content of malondialdehyde(MDA) in myocardial tissue were measured. The results showed that cardiac functions seemed to recover well after ischemia reperfusion injury in the group 2. The values of myocardial dynamics and hemodynamics indexes, including LVSP and ?dp/dt max , in the group 2 were obviously higher than those in the control group after ischemia reperfusion. The content of MDA in myocardial tissue was obviously lower in the group 2 than in the control group after ischemia and reperfusion. There was significant difference between Yixintang group 2 and control group ( P
