COMPARISON OF IMMUNOLOGIC EFFECT BETWEEN DIFFERENT IMMUNIZATION SCHEDULE OF ANTI-TETRODOTOXIN VACCINATION IN MICE
- VernacularTitle:河豚毒素抗毒疫苗不同免疫方案的免疫效果比较
- Author:
Qinhui XU
;
Kai HUANG
;
Kangtai RONG
- Publication Type:Journal Article
- Keywords:
tetrodotoxin;
artificial antigen;
chemical vaccine;
antibody;
immunization schedule
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Tetrodotoxin(TTX) was coupled to Tachypleus tridentatus hemocyanin (TTH) chemically to form an artificial antigen.Balb/c mice were immunized with TTX TTH. The immunologic effect of different immunization schedules [14～20d for longer interval (group L) and 7～10d for shorter interval (group S)] of experimental anti TTX vaccine was compared. The quality of antisera and effect of vaccine on TTX poisoning were detected. The antibody quality of serum was increased more quickly in group S than that in group L after immunization. The average survival rates were 99 3% and 92 9%, respectively ( P
